ABOUT
The Radoshevich lab was established in December 2017 in the Department of Microbiology and Immunology at the University of Iowa, Carver College of Medicine. We are a dynamic group with interests in cellular microbiology, immunology, mechanisms of bacterial survival and proteomics.
TEAM
Lilliana Radoshevich, PhD
Principal Investigator
Dr. Radoshevich completed her PhD at the University of California, San Francisco. There her work in the Debnath laboratory identified a novel substrate of the ubiquitin-like protein, ATG12 and demonstrated that the ATG12-ATG3 complex alters mitochondrial morphology. As a post-doctoral researcher under Pascale Cossart at the Institut Pasteur, she identified an early Interferon-independent induction of the ubiquitin-like protein ISG15. Her research also established that ISG15 could act as antibacterial effector following Listeria monocytogenes infection through a conjugation-dependent mechanism that correlates with increased cytokine secretion. Presently, at the University of Iowa she directs her own laboratory that uses cutting edge proteomics to study the effect of intracellular bacterial pathogens on ubiquitin-like proteins.
Emma Luhmann
Research Assistant
Emma graduated from Grinnell in 2018 and joined the laboratory shortly thereafter. She manages the laboratory and has become our proteomics specialist. She works on metabolic consequences of ISGylation and liver specific ISG15 functions.
Yifeng Zhang
PhD candidate
Yifeng came to the lab as a rotation student in February 2018 after having graduated from Luther College in 2017. Yifeng is interested in how ISGylation can affect cell-to-cell spread of Listeria monocytogenes in the liver and other epithelial tissues.
Ryan Callahan
PhD student, Microbiology
Ryan joined the laboratory in May of 2019 after graduating from North Dakota State University in 2018. He is interested in factors that contribute to the pathogenic potential of Listeria. He is also interested in changes to host ubiquitination provoked by infection.
Ellen Upton
PhD student, Immunology
Ellen joined the laboratory in May 2019 after having graduated from Grove City College in 2018 . Ellen is interested in how ISGylation affects immune cell recruitment following bacterial infection. She is also exploring the role of ISG15 as an antibacterial factor during other infections.
Alfredo Colina
University of Iowa PREP
Alfredo is a PREP scholar working in the laboratory for the 2019-2020 school year while he applies to graduate schools. He is assessing the consequences of ISG15 chain formation in infection and innate immune signaling.
Barbara Badovinac
Undergraduate student
Barbara is an ICRU fellow who started in the laboratory in March 2018. She is interested in research and has been assessing the consequences of ISGylation on modulators of autophagy and trafficking.